SPG21

1. SPG21 decreases intervertebral disc degeneration in rats.

   “CircSPG21 also ameliorated disc degeneration in the IVDD rat model, highlighting its potential as a therapeutic target.”

   Animalsin rat IVDD model

   CircSPG21 ameliorates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells and mitigates intervertebral disc degeneration through the miR-217/SIRT1 axis and mitophagy

   Stem cell research & therapy·7 Feb 2025

More on Intervertebral disc degeneration

1. SPG21 increases mitophagy in cells.

   “Overexpression of circSPG21 alleviated NPMSC senescence by reducing P21 and P53 levels and restoring mitophagy through Parkin.”

   Cellsoverexpression in TBHP-treated cellsnucleus pulposus-derived mesenchymal stem cells

   CircSPG21 ameliorates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells and mitigates intervertebral disc degeneration through the miR-217/SIRT1 axis and mitophagy

   Stem cell research & therapy·7 Feb 2025

More on Mitophagy

1. SPG21 decreases cellular senescence in cells.

   “Overexpression of circSPG21 alleviated NPMSC senescence by reducing P21 and P53 levels and restoring mitophagy through Parkin.”

   Cellsoverexpression in TBHP-treated cellsnucleus pulposus-derived mesenchymal stem cells

   CircSPG21 ameliorates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells and mitigates intervertebral disc degeneration through the miR-217/SIRT1 axis and mitophagy

   Stem cell research & therapy·7 Feb 2025

More on Cellular senescence