MIR217

1. MIR217 induces cellular senescence in human cells.

   “The miR-217 mimic facilitated cellular senescence”

   Cellsin HUVECs

   The role of miR-217/SIRT1 Axis in modulating the NLRP3 Inflammasome in the naturally aging thoracic aorta and in endothelial cells undergoing senescence induced by H₂O₂

   International immunopharmacology·29 Sep 2025

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1. MIR217 impairs angiogenic potential in human cells.

   “MiR-217 overexpression reduced FOXO3 but increased p16INK4a protein levels and impaired angiogenic potential in young HUVECs”

   CellsYoung HUVECs; miR-217 overexpressionhuman umbilical vein endothelial cells

   Regulation of endothelial cell senescence via the miR-217/FOXO3 axis

   Biogerontology·21 Jul 2025

1. MIR217 increases CDKN2A in human cells.

   “MiR-217 overexpression reduced FOXO3 but increased p16INK4a protein levels and impaired angiogenic potential in young HUVECs”

   CellsYoung HUVECs; miR-217 overexpressionhuman umbilical vein endothelial cells

   Regulation of endothelial cell senescence via the miR-217/FOXO3 axis

   Biogerontology·21 Jul 2025

More on CDKN2A

1. MIR217 decreases FOXO3 in human cells.

   “MiR-217 overexpression reduced FOXO3 but increased p16INK4a protein levels and impaired angiogenic potential in young HUVECs”

   CellsYoung HUVECs; miR-217 overexpressionhuman umbilical vein endothelial cells

   Regulation of endothelial cell senescence via the miR-217/FOXO3 axis

   Biogerontology·21 Jul 2025

More on FOXO3

1. MIR217 activates wnt/β-catenin signalling in mouse cells.

   “miR-217-5p attenuated SIRT1 expression and subsequently resulted in enhanced acetylation of β-catenin and Wnt signaling activation.”

   Cellsvia targeted inhibition of SIRT1

   Exosomes from senescent epithelial cells activate pulmonary fibroblasts via the miR-217-5p/Sirt1 axis in paraquat-induced pulmonary fibrosis

   Journal of translational medicine·26 Mar 2024

More on Wnt/β-catenin signalling