SORBS1

1. SORBS1 increases neuronal damage in human cells.

   “Mechanistically, SORBS1 interacted with FBXO22 to promote the ubiquitin-dependent degradation of BAG3, thereby amplifying calcium signaling, accelerating astrocyte senescence, and contributing to AD-related neuronal damage.”

   Cellsastrocyte-neuron co-culture model

   Single-cell Transcriptomics Reveals that the SORBS1/FBXO22/BAG3 Axis Drives Astrocyte Senescence via Calcium Signaling and Affects Alzheimer's Disease-Related Neuronal Damage

   Neuromolecular medicine·17 Jun 2026

1. SORBS1 increases cellular senescence in human cells.

   “Functional assays confirmed that SORBS1 accelerated astrocyte senescence.”

   Cellsin vitro AD model

   Single-cell Transcriptomics Reveals that the SORBS1/FBXO22/BAG3 Axis Drives Astrocyte Senescence via Calcium Signaling and Affects Alzheimer's Disease-Related Neuronal Damage

   Neuromolecular medicine·17 Jun 2026

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