SMPD1
GeneHomo sapiens2 papers3 findingsHGNC 11120NCBI Gene 6609Taxon 9606
- Humans1
- Cells1
Effects
1Mitophagy
downin human cells1
1 study
Mitophagy
downin human cells1
SMPD1 impairs mitophagy in human cells.
Cellsin PD models
Disrupted sphingolipid metabolism drives lysosomal and mitochondrial failure in Parkinson's disease · bioRxiv · 28 Sep 2026 · Preprint
Associations
2Stem cell exhaustion
upin human cells1
1 study
Stem cell exhaustion
upin human cells1
SMPD1 is associated with stem cell exhaustion in human cells.
Cellsskeletal muscle
Aged human muscle secretes an enzyme that impairs stem cell maintenance · bioRxiv · 2 Oct 2026 · Preprint
Postural Instability/Gait Difficulty
upin humans1
1 study
Postural Instability/Gait Difficulty
upin humans1
SMPD1 is associated with Postural Instability/Gait Difficulty in humans.
Humans
Disrupted sphingolipid metabolism drives lysosomal and mitochondrial failure in Parkinson's disease · bioRxiv · 28 Sep 2026 · Preprint
Latest
2Aged human muscle secretes an enzyme that impairs stem cell maintenance
Profiling conditioned media revealed that altered sphingolipid signaling reduces muscle stem cell pools in human cell cultures.
bioRxiv · Crisol B et al.
Disrupted sphingolipid metabolism drives lysosomal and mitochondrial failure in Parkinson's disease
A preprint shows SMPD1 upregulation collapses a sphingolipid salvage pathway, causing mitophagy defects and marking aggressive motor phenotypes.
bioRxiv · Rai S et al.