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SH2B1

Gene

2 papers2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Foundation for the National Institutes of Health and 7 more
  • Animals1
  • Model organisms1

Effects

1

Lifespan

downin mice1

1 study

  1. SH2B1 shortens lifespan in mice.

    “surprisingly, life span and oxidative resistance were reduced in SH2B1 null mice.”

    Animalsnull mice

    SH2B regulation of growth, metabolism, and longevity in both insects and mammals

    Cell metabolism22 Apr 2010

Associations

1

Type 2 diabetes

upin mice1

1 study

  1. SH2B1 raises the risk of type 2 diabetes in mice.

    “Genetic deletion of SH2B1 also resulted in growth retardation, obesity, and type 2 diabetes in mice”

    Animalsgenetic deletion

    SH2B regulation of growth, metabolism, and longevity in both insects and mammals

    Cell metabolism22 Apr 2010

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