SETD7
1 paper3 findings
- 1 lab in 1 country
- Funder: National Natural Science Foundation of China
- Humans1
Effects
2FOXO1
upin human cells1
1 study
FOXO1
upin human cells1
SETD7 increases FOXO1 in human cells.
“SETD7 enhanced AKT-dependent phosphorylation of FOXO1 at T24, promoting FOXO1 protein accumulation.”
Cellsin hESCs
Journal of assisted reproduction and genetics10 Dec 2025
Cellular senescence
upin human cells1
1 study
Cellular senescence
upin human cells1
SETD7 induces cellular senescence in human cells.
“SETD7 overexpression in hESCs induced senescence in a dose-dependent manner, increased expression of senescence markers, and severely suppressed PRL and IGFBP1 induction during decidualization.”
Cellsin hESCs
Journal of assisted reproduction and genetics10 Dec 2025
Associations
1Recurrent implantation failure
upin humans1
1 study
Recurrent implantation failure
upin humans1
SETD7 is associated with recurrent implantation failure in humans.
“SETD7 expression was significantly upregulated in RIF endometria compared with fertile controls; this correlated positively with senescence-associated genes and inversely with decidualization markers.”
Humansin RIF endometria compared with fertile controls
Journal of assisted reproduction and genetics10 Dec 2025
Latest
1 in 12 monthsJournal of Assisted Reproduction and Genetics
SETD7 regulates decidual senescence through FOXO1-dependent mechanisms in human endometrial stromal cells
Study in peopleCellular senescence