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set-6

Gene

3 papers2 findings

NCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 1 country
  • Funders: Natural Science Foundation of Guangdong Province and 1 more
  • Model organisms3

Effects

2

Lifespan

downin worms1

1 study

  1. set-6 shortens lifespan in worms.

    “Neuronal RNAi of set-6 and intestinal RNAi of met-2 accelerated hsp-6, atfs-1, ubl-5, and dve-1 expressions and extended lifespan of 6-PPDQ exposed nematodes.”

    Model organismsin 6-PPDQ exposed nematodes

    6-PPD quinone at environmentally relevant concentrations induced damage on longevity in C. elegans: Mechanistic insight from inhibition in mitochondrial UPR response

    The Science of the total environmentSep 13, 2024

Mitochondrial function

downin worms1

1 study

  1. set-6 impairs mitochondrial function in worms.

    “SET-6, accelerate behavioural deterioration in C. elegans by reducing mitochondrial function”

    Model organisms

    Two conserved epigenetic regulators prevent healthy ageing

    NatureFeb 26, 2020

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