BAZ2B

1. BAZ2B decreases MASH fibrosis in mice.

   “Baz2b in mice attenuates HEP senescence and MASH fibrosis”

   Animalsgenetic ablation or hepatocyte-specific knockdownliver

   Targeting the chromatin remodeler BAZ2B mitigates hepatic senescence and MASH fibrosis

   Nature aging·May 19, 2025

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1. BAZ2B decreases cellular senescence in mice.

   “ablation or hepatocyte-specific knockdown of Baz2b in mice attenuates HEP senescence”

   Animalsgenetic ablation or hepatocyte-specific knockdownliver

   Targeting the chromatin remodeler BAZ2B mitigates hepatic senescence and MASH fibrosis

   Nature aging·May 19, 2025

More on Cellular senescence

1. BAZ2B increases body-weight gain in mice.

   “ablation of Baz2b, the mouse orthologue of BAZ-2, attenuates age-dependent body-weight gain”

   Animalsablation

   Two conserved epigenetic regulators prevent healthy ageing

   Nature·Feb 26, 2020

1. BAZ2B increases cognitive decline in mice.

   “ablation of Baz2b, the mouse orthologue of BAZ-2, attenuates age-dependent body-weight gain and prevents cognitive decline in ageing mice”

   Animalsablation

   Two conserved epigenetic regulators prevent healthy ageing

   Nature·Feb 26, 2020

1. BAZ2B is associated with Alzheimer's disease in humans.

   “correlates positively with the progression of Alzheimer's disease”

   Humansfrontal cortex

   Two conserved epigenetic regulators prevent healthy ageing

   Nature·Feb 26, 2020

More on Alzheimer's disease