RND3
None of its findings points the other way.
- 2 independent labs in 2 countries
- Funders: ARC Foundation for Cancer Research and 7 more
- Humans1
- Animals3
Effects
3Cellular senescence
downin human cells1downin rats1
2 studies
Cellular senescence
downin human cells1downin rats1
RND3 protects against cellular senescence in rats.
“The deficiency of Rnd3 exacerbated cardiomyocyte senescence in vitro and in vivo.”
Animalsin diabetes / high glucose
Diabetes Advances Cardiomyocyte Senescence Through Interfering Rnd3 Expression and Function
Aging cell
RND3 inhibits cellular senescence in human cells.
“The growth alteration after RND3 silencing in HCC cells is not due to an increase of cell death but to the induction of senescence.”
Cellsshown by knockdown
Cancer gene therapy
TERT
downin human cells1
1 study
TERT
downin human cells1
RND3 decreases TERT in human cells.
“This RND3 knockdown-mediated phenomenon is dependent on the decrease of hTERT expression.”
CellsRND3 knockdown
Cancer gene therapy
Cell proliferation
downin human cells1
1 study
Cell proliferation
downin human cells1
RND3 decreases cell proliferation in human cells.
“silencing of RND3 induces a cell growth arrest both in vitro in 2D and 3D culture conditions and in vivo in tumor xenografts.”
CellsRND3 silencing
Cancer gene therapy
Associations
1Cardiac function
upin humans1
1 study
Cardiac function
upin humans1
RND3 is associated with cardiac function in humans.
“Rnd3 mRNA levels were reduced in peripheral blood mononuclear cells in diabetic patients, which was negatively correlated to patients age but positively correlated to cardiac function.”
Humansin diabetic patients
Diabetes Advances Cardiomyocyte Senescence through miR-103a-3p/Rnd3/STAT3 Signaling
medRxivPreprint