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AAV9-miR-103A-3P sponge

AAV9-miR-103A-3P sponge has been studied in 2 papers since 2024: 1 observational study in people, 1 in animals. The newest paper, Mar 2, 2025: “Diabetes Advances Cardiomyocyte Senescence Through Interfering Rnd3 Expression and Function”.

Intervention

2 papers study it2 findingsUpdated

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Key Research and Development Project of Hainan Province and 1 more
  • Humans1
  • Animals1

What did studies of AAV9-miR-103A-3P sponge find?

1

Studies of AAV9-miR-103A-3P sponge measured 1 outcome; the most studied are cellular senescence (2 studies).

Cellular senescence

downin rats2

2 studies

  1. AAV9-miR-103A-3P sponge decreases cellular senescence in rats.

    “Treatment with AAV9 vectors carrying miR-103a-3p sponges and Rnd3-overexpressing plasmids alleviated cardiomyocyte senescence and restored cardiac function in diabetic SD rats.”

    Animalsin diabetic SD rats

    Diabetes Advances Cardiomyocyte Senescence Through Interfering Rnd3 Expression and Function

    Aging cell

  2. AAV9-miR-103A-3P sponge decreases cellular senescence in rats.

    “AAV9 carrying miR-103a-3p sponges and Rnd3 -overexpressing plasmids mitigated cellular senescence in diabetic rats.”

    Animalsin diabetic rats

    Diabetes Advances Cardiomyocyte Senescence through miR-103a-3p/Rnd3/STAT3 Signaling

    medRxivPreprint

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