PRKAG1
None of its findings points the other way.
- 2 independent labs in 2 countries
- Funders: Deutsche Forschungsgemeinschaft and 3 more
- Animals3
- In silico2
Interventions
1Caloric restriction
upin rats1
1 study
Caloric restriction
upin rats1
Caloric restriction increases PRKAG1 in rats.
“AMPK-γ1 abundance was greater in the mitochondrial-enriched fraction of CR versus ad libitum muscles.”
Animalsconsuming 65% of ad libitum intakeskeletal muscleeight-weeksmales
Experimental gerontology
Associations
1Multidimensional frailty risk
downin humans1
1 study
Multidimensional frailty risk
downin humans1
PRKAG1 lowers the risk of multidimensional frailty risk in humans.
“Prkag1 expression declines with age in human tissues and is associated with multimorbidity and multidimensional frailty risk.”
Humans
Refeeding-associated AMPKγ1 complex activity is a hallmark of health and longevity
Nature aging
Latest
2 papers in 12 monthsComputer Methods in Biomechanics and Biomedical Engineering
Relationships between sarcopenia and Alzheimer's disease: screening for mitochondria-related biomarkers
Computational studySarcopenia
Computers in Biology and Medicine
Positive-Unlabelled learning for identifying new candidate Dietary Restriction-related genes among ageing-related genes
Computational studyMachine learning
Nature Aging
Refeeding-associated AMPKγ1 complex activity is a hallmark of health and longevity
Experiments in killifishInterventions