Computer Methods in Biomechanics and Biomedical Engineering · Dec 10, 2025

Relationships between sarcopenia and Alzheimer's disease: screening for mitochondria-related biomarkers

By He Q, Xia Y, Shen Q et al.

This study aims to identify mitochondrial-related biomarkers for sarcopenia and Alzheimer's disease (AD). Through the GEO database and machine learning algorithms, three diagnostic biomarkers (FKBP5, PRKAG1, and FBP2) were identified, and the constructed models showed good diagnostic accuracy in both internal and external datasets. Furthermore, multiple analyses such as GSEA, immune infiltration, and drug prediction were conducted. These findings provide new insights into shared pathological mechanisms and clinical diagnosis and treatment of sarcopenia and AD. Further clinical and experimental studies are needed to validate these results.

doi.org/10.1080/10255842.2025.2598656PubMed 41368712Biomarkers