Lipid droplet and cholesterol ester load
downin human cells1
PLA2G2F decreases lipid droplet and cholesterol ester load in human cells.
“Neuronal PLA2G2F mediates intercellular signaling to decrease lipid droplet and cholesterol ester load in human induced pluripotent stem cell-derived microglia.”
Cellsneuronal PLA2G2F-mediated intercellular signalinginduced pluripotent stem cell-derived microglia
Boosting a secreted enzyme protected memory in aging mice
Nature neuroscience15 Oct 2026
Synapse loss
downin mice1
PLA2G2F decreases synapse loss in mice.
“Pla2g2f deletion in DGCs exacerbates aging-associated pathophysiological changes, including synapse loss”
Animalsshown by Pla2g2f deletion in DGCsdentate granule cell
Boosting a secreted enzyme protected memory in aging mice
Nature neuroscience15 Oct 2026
Hippocampal-dependent memory
upin mice1
PLA2G2F improves hippocampal-dependent memory in mice.
“Pla2g2f deletion in DGCs exacerbates aging-associated pathophysiological changes, including synapse loss, inflammatory microglia, reactive astrogliosis, impaired neurogenesis, lipid dysregulation, lipid droplet accumulation and hippocampal-dependent memory loss.”
Animalsshown by Pla2g2f deletion in DGCsdentate granule cell
Boosting a secreted enzyme protected memory in aging mice
Nature neuroscience15 Oct 2026
Cognitive resilience
upin humans1
PLA2G2F is associated with cognitive resilience in humans.
“whose expression increases in DGCs during aging and is associated with cognitive resilience in humans.”
Humans
Boosting a secreted enzyme protected memory in aging mice
Nature neuroscience15 Oct 2026
Experiments in mice suggested that an enzyme released by nerve cells helps compensate for age-related brain changes and preserve memory.Experiments in mice suggested that an enzyme released by nerve cells helps compensate for age-related brain changes and preserve memory.