There are 7 papers on PLA2G2A in aging research: 4 observational studies in people, 1 in animals, 1 in cells.
1 new paper in 30 daysSee all 7 papers on PLA2G2A
At a glance
The findings reach mice, none yet in people. 2 independent labs in 1 country.
None of its findings points the other way.
- 2 independent labs in 1 country
- Funder: National Natural Science Foundation of China
- Humans4
- Animals1
- Cells1
- In silico1
Interventions
1Gushudan
downin rats1
1 study
Gushudan
downin rats1
Gushudan decreases PLA2G2A in postmenopausal osteoporosis rats.
“suggesting that GSD might ameliorate the lipid-inflammatory crosstalk disorder in PMOP rats by downregulating Pla2g2a expression”
Animalsin postmenopausal osteoporosis rats
Analytical and bioanalytical chemistry
Effects
2Cellular senescence
mediatesin human cells1
1 study
Cellular senescence
mediatesin human cells1
PLA2G2A mediates cellular senescence in human cells (PFDA-induced cell senescence suppression).
“Knockdown with sPLA2-IIA siRNA provided additional evidence that sPLA2-IIA was a mediator of PFDA-induced cell senescence suppression.”
CellsPFDA-induced cell senescence suppression
Perfluorodecanoic acid (PFDA) promotes gastric cell proliferation via sPLA2-IIA
Oncotarget
Cell proliferation
downin human cells1
1 study
Cell proliferation
downin human cells1
PLA2G2A decreases cell proliferation in human cells (expression plasmid transfection) (>30%).
“Cells transfected with expression plasmids pENTER-tcf4 and pENTER-pla2g2a show reduced cell proliferation by more than 60% and 30% respectively.”
Cellsexpression plasmid transfection
Perfluorodecanoic acid (PFDA) promotes gastric cell proliferation via sPLA2-IIA
Oncotarget