Cellular senescence
downin mice1
PCK2 prevents cellular senescence in mice.
“PCK2 loss reduced oxidative phosphorylation and ATP production, increased mitochondrial superoxide, activated p53/p21-associated senescence”
Animalsshown by osteoblast-specific conditional knockout
Scaffold and metformin sped new bone formation in aged mice
Nano Research14 Sep 2026
Oxidative phosphorylation
is required forin mice1
PCK2 is required for oxidative phosphorylation in mice.
“In senescent hBMSCs and osteoblast-specific Pck2 conditional knockout mice, PCK2 loss reduced oxidative phosphorylation and ATP production”
Animalsshown by osteoblast-specific conditional knockout
Scaffold and metformin sped new bone formation in aged mice
Nano Research14 Sep 2026
A bone-supporting scaffold plus metformin accelerated new bone formation in aged mice, most clearly when bone-forming cells lacked a protein involved in energy…A bone-supporting scaffold plus metformin accelerated new bone formation in aged mice, most clearly when bone-forming cells lacked a protein involved in energy metabolism.