PAK2
- 2 independent labs in 2 countries
- 1 finding against
- Funder: National Institute of General Medical Sciences
- Cells2
Effects
2Cellular senescence
downin human cells1upin human cells1
2 studies
Cellular senescence
downin human cells1upin human cells1
PAK2 protects against cellular senescence in human cells.
“PAK2 overexpression provided additional protection.”
Cellsurine exosome stimulation
Icariin Attenuates Human Renal Tubular Epithelial Cell Senescence by Targeting PAK2 via miR-23b-3p
Current pharmaceutical biotechnology1 Jan 2024
PAK2 increases cellular senescence in human cells.
“depletion of Pak2 delayed oncogene-induced senescence in IMR90 human fibroblasts”
Cellsoncogene-induced senescence
Pak2 kinase promotes cellular senescence and organismal aging
Proceedings of the National Academy of Sciences of the United States of America17 Jun 2019
Lifespan
downin mice1
1 study
Lifespan
downin mice1
PAK2 shortens lifespan in mice.
“depletion of Pak2 in BubR1 progeroid mice attenuated the onset of aging-associated phenotypes and extended life span.”
AnimalsBubR1 progeroid mice
Pak2 kinase promotes cellular senescence and organismal aging
Proceedings of the National Academy of Sciences of the United States of America17 Jun 2019
Upstream
1MIR23B
downin human cells1
1 study
MIR23B
downin human cells1
MIR23B decreases PAK2 in human cells.
“Urine exosome stimulation up-regulated miR-23b-3p expression, which in turn suppressed PAK2 expression.”
Cellsin HK-2 cells
Icariin Attenuates Human Renal Tubular Epithelial Cell Senescence by Targeting PAK2 via miR-23b-3p
Current pharmaceutical biotechnology1 Jan 2024