npp-16

1. npp-16 extends lifespan in worms.

   “NPP-16/NUP50 promotes transcriptional activation of lipid catabolism to extend the lifespan of Caenorhabditis elegans independently of its role in nuclear transport.”

   Model organisms

   The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity

   Molecular cell·23 Sep 2025

2. npp-16 extends lifespan in worms.

   “In turn, NPP-16/NUP50 promotes transcriptomic activation of lipid catabolism to extend the lifespan of Caenorhabditis elegans independently of its role in nuclear transport.”

   Model organisms

   The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity

   bioRxiv : the preprint server for biology·17 Feb 2025Preprint

1. npp-16 activates lipid and ceramide metabolism in worms.

   “NPP-16/NUP50 promotes transcriptional activation of lipid catabolism to extend the lifespan of Caenorhabditis elegans”

   Model organisms

   The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity

   Molecular cell·23 Sep 2025

More on Lipid and ceramide metabolism

1. npp-16 activates fatty acid β-oxidation in worms.

   “NPP-16/NUP50 promotes transcriptomic activation of lipid catabolism”

   Model organisms

   The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity

   bioRxiv : the preprint server for biology·17 Feb 2025Preprint

More on Fatty acid β-oxidation

1. AMPK signalling increases npp-16 in worms.

   “AMP-activated protein kinase (AMPK), post-translationally regulates the abundance of the nucleoporin NPP-16/NUP50 in response to nutrient availability and energetic stress.”

   Model organisms

   The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity

   Molecular cell·23 Sep 2025

More on AMPK signalling