NAT8
- Animals3
Effects
2Mortality
upin mice1
1 study
Mortality
upin mice1
NAT8 increases mortality in mice.
“Overexpression of either ATase at conception was found to be lethal”
Animalsoverexpression at conception
Overexpression of ATase1 and ATase2 disrupts the secretome and causes a progeria phenotype
Life science allianceAug 29, 2025
Progeria-like phenotype
upin mice1
1 study
Progeria-like phenotype
upin mice1
NAT8 induces progeria-like phenotype in mice.
“overexpression at birth was found to cause a progeria-like phenotype that included skin alterations, lordokyphosis, reduced bone density, sarcopenia, splenomegaly, adenomegaly, and systemic inflammation.”
Animalsoverexpression at birth
Overexpression of ATase1 and ATase2 disrupts the secretome and causes a progeria phenotype
Life science allianceAug 29, 2025
Latest
Life Science Alliance
Overexpression of ATase1 and ATase2 disrupts the secretome and causes a progeria phenotype
Experiments in miceMechanisms