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NAT8B

Gene

2 papers2 findings

Taxon

  • Animals2

Effects

2

Mortality

upin mice1

1 study

  1. NAT8B increases mortality in mice.

    “Overexpression of either ATase at conception was found to be lethal”

    Animalsoverexpression at conception

    Overexpression of ATase1 and ATase2 disrupts the secretome and causes a progeria phenotype

    Life science allianceAug 29, 2025

Progeria-like phenotype

upin mice1

1 study

  1. NAT8B induces progeria-like phenotype in mice.

    “overexpression at birth was found to cause a progeria-like phenotype that included skin alterations, lordokyphosis, reduced bone density, sarcopenia, splenomegaly, adenomegaly, and systemic inflammation.”

    Animalsoverexpression at birth

    Overexpression of ATase1 and ATase2 disrupts the secretome and causes a progeria phenotype

    Life science allianceAug 29, 2025

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