MIR410

1. MIR410 inhibits AIFM1 in human cells.

   “It alleviates TNF-α-induced NPCs senescence, inflammation, and ECM degradation by targeting AIFM1”

   Cellsin TNF-α-induced nucleus pulposus cells

   Aberrant miR-410-5p expression occurs in human lumbar intervertebral disk degeneration and improves nucleus pulposus cell degeneration by targeting AIFM1

   Nucleosides, nucleotides & nucleic acids·2 Mar 2026

More on AIFM1

1. MIR410 increases extracellular matrix remodelling in human cells.

   “and promoted ECM-related genes (COL2A1, ACAN), while AIFM1 overexpression reversed these effects.”

   Cellsin TNF-α-induced nucleus pulposus cells

   Aberrant miR-410-5p expression occurs in human lumbar intervertebral disk degeneration and improves nucleus pulposus cell degeneration by targeting AIFM1

   Nucleosides, nucleotides & nucleic acids·2 Mar 2026

More on Extracellular matrix remodelling

1. MIR410 decreases inflammation in human cells.

   “MiR-410-5p overexpression reduced senescence markers (p16, p21, SA-β-gal activity), inflammatory factors (IL-1β and IL-6)”

   Cellsin TNF-α-induced nucleus pulposus cells

   Aberrant miR-410-5p expression occurs in human lumbar intervertebral disk degeneration and improves nucleus pulposus cell degeneration by targeting AIFM1

   Nucleosides, nucleotides & nucleic acids·2 Mar 2026

More on Inflammation

1. MIR410 decreases cellular senescence in human cells.

   “MiR-410-5p overexpression reduced senescence markers (p16, p21, SA-β-gal activity), inflammatory factors (IL-1β and IL-6), and promoted ECM-related genes (COL2A1, ACAN)”

   Cellsin TNF-α-induced nucleus pulposus cells

   Aberrant miR-410-5p expression occurs in human lumbar intervertebral disk degeneration and improves nucleus pulposus cell degeneration by targeting AIFM1

   Nucleosides, nucleotides & nucleic acids·2 Mar 2026

More on Cellular senescence