mir-229

mir-229 extends lifespan in worms.

“identified a conserved C. elegans miRNA cluster (miR-229/64/65/66) that is required for normal adult lifespan, with overexpression significantly extending longevity”

Reviewshown by overexpression

miR-425-5p Regulates Cellular Senescence Through Modulation of Retinoblastoma Protein Phosphorylation

bioRxiv (Cold Spring Harbor Laboratory)·19 Jun 2026Preprint