METALLOTHIONEIN

1. METALLOTHIONEIN decreases nitrative damage to 2-OGD.

   “MT inhibited NF-κB activation and associated nitrative damage to cardiac 2-OGD in both old MT-TG hearts and TNF-α-treated H9c2MT7 cardiomyocytes”

   Animalsin both old MT-TG hearts and TNF-α-treated H9c2MT7 cardiomyocytes

   Metallothionein Prevents Age-Associated Cardiomyopathy via Inhibiting NF-κB Pathway Activation and Associated Nitrative Damage to 2-OGD

   Antioxidants & redox signaling·6 Sep 2016

More on Nitrative damage to 2-OGD

1. METALLOTHIONEIN inhibits NF-κB signalling in mice.

   “aging-accompanied NF-κB activation, characterized by increased nuclear p65 translocation, elevated DNA-binding activity, and upregulation of inflammatory cytokines, was largely attenuated by MT overexpression.”

   Animalsheartmales

   Metallothionein Prevents Age-Associated Cardiomyopathy via Inhibiting NF-κB Pathway Activation and Associated Nitrative Damage to 2-OGD

   Antioxidants & redox signaling·6 Sep 2016

More on NF-κB signalling

1. METALLOTHIONEIN prevents cardiac hypertrophy in mice.

   “Histomorphology and echocardiographic analysis revealed that age-associated cardiac hypertrophy, remodeling, and dysfunction were ameliorated in MT-TG mice.”

   Animalsheartmales

   Metallothionein Prevents Age-Associated Cardiomyopathy via Inhibiting NF-κB Pathway Activation and Associated Nitrative Damage to 2-OGD

   Antioxidants & redox signaling·6 Sep 2016