Nitrative damage to 2-OGD

1. METALLOTHIONEIN decreases nitrative damage to 2-OGD.

   “MT inhibited NF-κB activation and associated nitrative damage to cardiac 2-OGD in both old MT-TG hearts and TNF-α-treated H9c2MT7 cardiomyocytes”

   Animalsin both old MT-TG hearts and TNF-α-treated H9c2MT7 cardiomyocytes

   Metallothionein Prevents Age-Associated Cardiomyopathy via Inhibiting NF-κB Pathway Activation and Associated Nitrative Damage to 2-OGD

   Antioxidants & redox signaling·Sep 6, 2016

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1. NF-κB signalling increases nitrative damage to 2-OGD.

   “The NF-κB activation was further proved to be pivotal for both age-associated and TNF-α-induced nitrative damage to cardiac 2-oxoglutarate dehydrogenase (2-OGD) by virtue of NF-κB p65 gene silencing.”

   Animalsage-associated and TNF-α-inducedheart

   Metallothionein Prevents Age-Associated Cardiomyopathy via Inhibiting NF-κB Pathway Activation and Associated Nitrative Damage to 2-OGD

   Antioxidants & redox signaling·Sep 6, 2016

More on NF-κB signalling