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OGDH

Gene

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: American Heart Association and 2 more
  • Animals1

Interventions

1

4-hydroxy-2-nonenal

downin rat cells1

1 study

  1. 4-hydroxy-2-nonenal inhibits OGDH in rat cells.

    “alpha-Ketoglutarate dehydrogenase is highly susceptible to 4-hydroxy-2-nonenal inactivation in vitro”

    Cellsin vitro

    Declines in mitochondrial respiration during cardiac reperfusion: age-dependent inactivation of alpha-ketoglutarate dehydrogenase

    Proceedings of the National Academy of Sciences of the United States of America8 Jun 1999

More on 4-hydroxy-2-nonenal

Effects

1

Mitochondrial respiration

mediatesin rats1

1 study

  1. OGDH mediates mitochondrial respiration in rats.

    “inactivation of alpha-ketoglutarate dehydrogenase is responsible, in large part, for observed reperfusion-induced declines in NADH-linked respiration”

    Animalsreperfusionheart

    Declines in mitochondrial respiration during cardiac reperfusion: age-dependent inactivation of alpha-ketoglutarate dehydrogenase

    Proceedings of the National Academy of Sciences of the United States of America8 Jun 1999

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