ING1

1. ING1 inhibits metabolic activity in monkey cells.

   “ING1a inhibited metabolic activity in numerous primary and established human cells and in Macaca mulatta fibroblasts, but not in murine fibroblasts.”

   CellsING1a expression

   A recently evolved domain of the human ING1 epigenetic regulator targets mitochondria and induces senescence

   Cellular and molecular life sciences : CMLS·30 Jan 2026

2. ING1 inhibits metabolic activity in human cells.

   “ING1a inhibited metabolic activity in numerous primary and established human cells and in Macaca mulatta fibroblasts, but not in murine fibroblasts.”

   CellsING1a expression

   A recently evolved domain of the human ING1 epigenetic regulator targets mitochondria and induces senescence

   Cellular and molecular life sciences : CMLS·30 Jan 2026

1. ING1 inhibits clathrin-mediated endocytosis in human cells.

   “Overexpression of ING1a rapidly induces cell senescence in human cells by affecting transcription to inhibit endocytosis”

   Cellsoverexpression

   A recently evolved domain of the human ING1 epigenetic regulator targets mitochondria and induces senescence

   Cellular and molecular life sciences : CMLS·30 Jan 2026

More on Clathrin-mediated endocytosis

1. ING1 induces cellular senescence in human cells.

   “Overexpression of ING1a rapidly induces cell senescence in human cells by affecting transcription to inhibit endocytosis and activate the retinoblastoma (Rb) cell cycle checkpoint pathway.”

   Cellsoverexpression

   A recently evolved domain of the human ING1 epigenetic regulator targets mitochondria and induces senescence

   Cellular and molecular life sciences : CMLS·30 Jan 2026

More on Cellular senescence