LARP7

1. LARP7 is required for cellular homeostasis in human cells.

   “The tube formation and transwell assays further supported the hypothesis that LIR's beneficial impact on endothelial dysfunction depends on the LARP7/SIRT1 signaling axis.”

   Cellsin high glucose-induced endothelial cell senescence and dysfunction

   Liraglutide Attenuates Endothelial Dysfunction by Inhibiting Hyperglycemia-Induced Endothelial Cell Senescence Through the LARP7/SIRT1 Pathway

   Archivum immunologiae et therapiae experimentalis·4 Dec 2025

More on Cellular homeostasis

1. LARP7 decreases atherosclerotic lesion area in mice.

   “Consequently, Larp7 overexpression led to a reduction in the area of atherosclerotic lesions in HFD-fed ApoEKO; Larp7tetO mice.”

   AnimalsLarp7 overexpression in HFD-fed ApoEKO; Larp7tetO miceaorta

   LARP7 overexpression alleviates aortic senescence and atherosclerosis

   Journal of cellular and molecular medicine·31 May 2024

1. LARP7 decreases SASP factors in mice.

   “Furthermore, Larp7 overexpression resulted in a decrease in pro-inflammatory macrophages and SASP factors.”

   AnimalsLarp7 overexpression in HFD-fed ApoEKO; Larp7tetO mice

   LARP7 overexpression alleviates aortic senescence and atherosclerosis

   Journal of cellular and molecular medicine·31 May 2024

More on SASP factors

1. LARP7 decreases pro-inflammatory macrophages in mice.

   “Furthermore, Larp7 overexpression resulted in a decrease in pro-inflammatory macrophages and SASP factors.”

   AnimalsLarp7 overexpression in HFD-fed ApoEKO; Larp7tetO mice

   LARP7 overexpression alleviates aortic senescence and atherosclerosis

   Journal of cellular and molecular medicine·31 May 2024

More on Pro-inflammatory macrophages

1. LARP7 decreases P16-POSITIVE senescent cells in mice.

   “Additionally, Larp7 overexpression reduced the presence of p16-positive senescent cells in the aortic lesions.”

   AnimalsLarp7 overexpression in HFD-fed ApoEKO; Larp7tetO miceaortic lesions

   LARP7 overexpression alleviates aortic senescence and atherosclerosis

   Journal of cellular and molecular medicine·31 May 2024

More on P16-POSITIVE senescent cells

1. LARP7 increases SIRT1 in mice.

   “Larp7 overexpression led to increased Sirt1 activity and decreased cellular senescence signals mediated by p53/p65 in the aortas.”

   AnimalsLarp7 overexpression in HFD-fed ApoEKO; Larp7tetO miceaorta

   LARP7 overexpression alleviates aortic senescence and atherosclerosis

   Journal of cellular and molecular medicine·31 May 2024

More on SIRT1