Lam

1. Lam shortens lifespan in flies.

   “Ubiquitous lamin-B expression improves locomotor activity of the male flies at the expense of lower stress resistance and shorten lifespan.”

   Model organismsmales

   Altered stability of nuclear lamin-B marks the onset of aging in male Drosophila

   PloS one·Mar 24, 2022

2. Lam shortens lifespan in flies.

   “induced expression of the farnesylated lamina proteins Lamin B and Kugelkern cause aberrant nuclear shapes and reduce the lifespan of adult flies”

   Model organismsinduced expression

   The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging-like phenotypes in Drosophila flies

   Aging cell·Jul 10, 2008

1. Lam inhibits telomeric homologous recombination in flies.

   “Both DNA damage and activation of homologous recombination in the telomeres were observed in the germ cells of lamin B mutants.”

   Model organismsshown by lamin B mutationgerm cell

   Dysfunction of Lamin B and Physiological Aging Cause Telomere Instability in Drosophila Germline

   Biochemistry. Biokhimiia·Dec 1, 2022

1. Lam protects against telomeric DNA damage in flies.

   “Both DNA damage and activation of homologous recombination in the telomeres were observed in the germ cells of lamin B mutants.”

   Model organismsshown by lamin B mutationgerm cell

   Dysfunction of Lamin B and Physiological Aging Cause Telomere Instability in Drosophila Germline

   Biochemistry. Biokhimiia·Dec 1, 2022

1. Lam inhibits transcriptional activation of transposable elements and telomeric repeats in flies.

   “the impaired localization of lamin B leads to the heterochromatin decompaction and transcriptional activation of some transposable elements and telomeric repeats.”

   Model organismsshown by lamin B mutation and impaired localizationgermline

   Dysfunction of Lamin B and Physiological Aging Cause Telomere Instability in Drosophila Germline

   Biochemistry. Biokhimiia·Dec 1, 2022

1. Lam protects against heterochromatin decompaction in flies.

   “the impaired localization of lamin B leads to the heterochromatin decompaction”

   Model organismsshown by lamin B mutation and impaired localizationgermline

   Dysfunction of Lamin B and Physiological Aging Cause Telomere Instability in Drosophila Germline

   Biochemistry. Biokhimiia·Dec 1, 2022

1. Lam improves locomotor activity in flies.

   “Ubiquitous lamin-B expression improves locomotor activity of the male flies at the expense of lower stress resistance and shorten lifespan.”

   Model organismsmales

   Altered stability of nuclear lamin-B marks the onset of aging in male Drosophila

   PloS one·Mar 24, 2022

1. Lam decreases DNA damage in flies.

   “Depletion of the Drosophila lamin-B in the young or larval fat body results in a reduction of heterochromatin and a corresponding increase in retrotransposon expression and DNA damage.”

   Model organismsshown by lamin-B depletionfat body

   Age-associated de-repression of retrotransposons in the Drosophila fat body, its potential cause and consequence

   Aging cell·Apr 12, 2016

1. Lam decreases retrotransposon expression in flies.

   “Depletion of the Drosophila lamin-B in the young or larval fat body results in a reduction of heterochromatin and a corresponding increase in retrotransposon expression”

   Model organismsshown by lamin-B depletionfat body

   Age-associated de-repression of retrotransposons in the Drosophila fat body, its potential cause and consequence

   Aging cell·Apr 12, 2016

More on Retrotransposon expression

1. Lam increases heterochromatin in flies.

   “Depletion of the Drosophila lamin-B in the young or larval fat body results in a reduction of heterochromatin”

   Model organismsshown by lamin-B depletionfat body

   Age-associated de-repression of retrotransposons in the Drosophila fat body, its potential cause and consequence

   Aging cell·Apr 12, 2016