INSULIN

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended over a year ago with no results on ClinicalTrials.gov and no paper reporting them.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

Includes the processes named after it and trials of drugs aimed at it.

44 independent labs in 16 countries
3 findings against
364 trials, 94 with no results posted

Funders: National Institute on Aging and others
2 of 64 findings with company ties
305 of 364 trials sponsored by developers of drugs on it

Model organisms2

Interventions

Neuropeptide y

upin rat cells1

1 study

Neuropeptide y increases INSULIN in rat cells.
“Insulin expression was also increased in an ERK-dependent manner in cultured Drosophila central nervous system (CNS) cells and in rat pancreatic cells treated with sNPF or NPY peptide, respectively.”
Cellstreated with sNPF or NPY peptide
Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling
Nature cell biology16 Mar 2008

Effects

Oogenesis

upin H. saltator1

1 study

INSULIN induces oogenesis in H. saltator.
“Insulin is upregulated in the gamergate brain that leads to oogenesis, but surprisingly correlates with extended longevity.”
Model organismsgamergatesbrain
Insulin signaling and extended longevity in ants
bioRxiv (Cold Spring Harbor Laboratory)29 Jun 2022Preprint