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ink4ab

Gene

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Animals1

Effects

2

Spontaneous cancer

downin Vertebrata1

1 study

  1. ink4ab protects against spontaneous cancer in Vertebrata.

    “Adult Ink4ab-deficient animals failed to activate senescence and developed spontaneous cancers.”

    Animalsshown by Ink4ab deficiency

    Evolutionary conserved reciprocal senescence and tumor suppressor signals limit lifetime cancer

    bioRxiv (Cold Spring Harbor Laboratory)29 Dec 2024Preprint

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Cellular senescence

upin Vertebrata1

1 study

  1. ink4ab induces cellular senescence in Vertebrata.

    “This ink4ab triggers senescence upon oxidative- and/or carcinogenic-stress.”

    Animalsunder oxidative and/or carcinogenic stress

    Evolutionary conserved reciprocal senescence and tumor suppressor signals limit lifetime cancer

    bioRxiv (Cold Spring Harbor Laboratory)29 Dec 2024Preprint

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