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HSPB8

Gene

1 paper1 finding

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Heart, Lung, and Blood Institute and 1 more
  • Animals1

Effects

1

Lifespan

downin mice1−48% mean life span

1 study

  1. HSPB8 shortens lifespan in mice (-48% mean life span).

    “Survival curves revealed that TG mice had a 48% reduction in their mean life span compared to wild type (WT) mice.”

    Animalscardiac-specific overexpressionheart

    Hsp22 overexpression induces myocardial hypertrophy, senescence and reduced life span through enhanced oxidative stress

    Free radical biology & medicine29 Apr 2019

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