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GSTM3

Gene

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

  • 1 lab
  • Animals1

Interventions

1

Caloric restriction

upin mice1

1 study

  1. Caloric restriction increases GSTM3 in mice.

    “Both CR and EODF significantly upregulated the expression of GSTM3 in the liver, mediated by the transcription factor CREB1.”

    Animalsmatched caloric restriction in MAFLD miceliver56 days

    Caloric Restriction Ameliorates MAFLD by Upregulating CREB1-Dependent GSTM3 Expression and Enhancing Mitochondrial Function

    ADA Scientific Sessions 2025 abstract13 Jun 2025

More on Caloric restriction

Effects

2

Fatty acid β-oxidation

upin mice1

1 study

  1. GSTM3 activates fatty acid β-oxidation in mice.

    “overexpression of GSTM3 significantly alleviated liver lipid accumulation, inflammation, and insulin resistance, improved mitochondrial function, and promoted fatty acid oxidation.”

    Animalsliver-specific overexpression in mouse models of MAFLDliver

    Caloric Restriction Ameliorates MAFLD by Upregulating CREB1-Dependent GSTM3 Expression and Enhancing Mitochondrial Function

    ADA Scientific Sessions 2025 abstract13 Jun 2025

More on Fatty acid β-oxidation

Liver lipid accumulation

downin mice1

1 study

  1. GSTM3 decreases liver lipid accumulation in mice.

    “overexpression of GSTM3 significantly alleviated liver lipid accumulation, inflammation, and insulin resistance, improved mitochondrial function, and promoted fatty acid oxidation.”

    Animalsliver-specific overexpression in mouse models of MAFLDliver

    Caloric Restriction Ameliorates MAFLD by Upregulating CREB1-Dependent GSTM3 Expression and Enhancing Mitochondrial Function

    ADA Scientific Sessions 2025 abstract13 Jun 2025

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