GPC6

GPC6 mediates synaptic loss in human cells.

“a CRISPRi screen in TDP-43 knock-down iNeurons identified GPC6, a human ortholog of Dlp, as a significant contributor to TDP-43 dependent synaptic loss.”

Cellsin TDP-43 knock-down iNeurons

C9orf72 -associated G4C2 hexanucleotide repeat expression in Drosophila mushroom bodies causes age dependent TDP-43 pathology and dementia relevant phenotypes mediated in part by the glypican Dlp/GPC6

bioRxiv : the preprint server for biology·May 12, 2026Preprint