TBPH

4 papers study it3 findings

NCBI Gene Taxon

2 independent labs in 2 countries

Funders: National Natural Science Foundation of China and 2 more

Model organisms4

Effects

2

Lifespan

downin flies1

1 study

TBPH shortens lifespan in flies.
“Neuronal TBPH RNAi consistently shortened lifespan, with males and females exhibiting distinct survival profiles.”
Model organismsneuronal TBPH RNAi
Dicer Is Involved in Cytotoxicity and Motor Impairment Induced by TBPH Deficiency
Current issues in molecular biologyJun 10, 2025

Dcr-1

downin flies1

1 study

TBPH decreases Dcr-1 in flies.
“A TBPH knockout significantly reduced mRNA transcription and protein levels of DCR-1 and DCR-2”
Model organismsTBPH knockout
Dicer Is Involved in Cytotoxicity and Motor Impairment Induced by TBPH Deficiency
Current issues in molecular biologyJun 10, 2025

Upstream

1

Su(var)3-9

downin flies1

1 study

Su(var)3-9 decreases TBPH in flies.
“augmented Su(var)3-9 activity causes a decrease in TDP-43 expression”
Model organismsbrain
Su(var)3-9 mediates age-dependent increase in H3K9 methylation on TDP-43 promoter triggering neurodegeneration
Cell death discoverySep 27, 2023

More on Su(var)3-9

Latest

1 paper in 12 months

bioRxivMay 25

C9orf72 -associated G4C2 hexanucleotide repeat expression in Drosophila mushroom bodies causes age dependent TDP-43 pathology and dementia relevant phenotypes mediated in part by the glypican Dlp/GPC6

Preprint: experiments in fliesC9ORF72

Current Issues in Molecular BiologyJul 23

Dicer Is Involved in Cytotoxicity and Motor Impairment Induced by TBPH Deficiency

Experiments in fliesMechanisms

FASEB JournalDec 5

Outstretched wing is controlled by intestinal enteroblasts-derived unpaired 2 cytokine signaling in Drosophila

Experiments in fliesNotch signaling

Cell Death DiscoverySep 28

Su(var)3-9 mediates age-dependent increase in H3K9 methylation on TDP-43 promoter triggering neurodegeneration

Experiments in fliesMechanisms