There are 3 papers on Acon in aging research: none in people yet, 3 in animals.
At a glance
The findings reach worms or flies, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Funder: National Research Foundation of Korea
- Model organisms3
Effects
4Mitophagy
upin flies1
1 study
Mitophagy
upin flies1
Acon increases mitophagy in flies (labeled with mt-Keima).
“mAcon1 overexpression in Kenyon cells induced mitophagy labeled with mt-Keima and improved learning ability.”
Model organismslabeled with mt-KeimaKenyon cell
Aging cell
Autophagy
upin flies1
1 study
Autophagy
upin flies1
Acon increases autophagy in flies (measured by Atg8a-II and p62 levels).
“Autophagy activity and efficacy determined by the positive and negative changes in the expression levels of Atg8a-II and p62 were proportional to the expression level of mAcon1.”
Model organismsmeasured by Atg8a-II and p62 levels
Aging cell
Learning and memory
upin flies1
1 study
Learning and memory
upin flies1
Acon improves learning and memory in flies (age-related memory impairment, shown by neuronal overexpression).
“Neuronal overexpression of mAcon1 extended its lifespan and improved AMI.”
Model organismsage-related memory impairment, shown by neuronal overexpressionneuron
Aging cell
Lifespan
upin flies1
1 study
Lifespan
upin flies1
Acon extends lifespan in flies (shown by neuronal overexpression).
“Neuronal overexpression of mAcon1 extended its lifespan and improved AMI.”
Model organismsshown by neuronal overexpressionneuron
Aging cell