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2Peripheral immune cell profiles predict cognitive decline in older adults
An immune risk score tracking immunosenescence correlated with markers of neural injury and neuroinflammation rather than classical amyloid or tau pathology.
Age and ageing · Luan H et al.
Astrocytic BAG3 regulates protein clearance systems linked to Alzheimer disease
Loss of the chaperone mediator in human astrocytes disrupts autophagy, proteasomes, and retromer traffic while impairing amyloid-beta proteostasis in neuron cocultures.
Proceedings of the National Academy of Sciences of the United States of America · Augur ZM et al.