FFAR3ANDFFAR2

Gene

1 paper1 finding

  • 1 lab
  • Animals1

Effects

1

Bone protection

is required forin mice1

1 study
  1. FFAR3ANDFFAR2 is required for bone protection in mice.

    “GPR41/GPR43 deficiency abolished the benefits of metformin, propionate, and butyrate.”

    AnimalsBenefits of metformin, propionate, and butyrate; shown by GPR41/GPR43 deficiencybone

    Gut microbe products helped metformin protect bone in mice

    European journal of pharmacology14 Oct 2026

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European Journal of Pharmacology

Gut microbe products helped metformin protect bone in mice

Experiments in mice with ovaries removed linked the drug’s bone benefits to short-chain fatty acids, small molecules made by gut bacteria.Experiments in mice with ovaries removed linked the drug’s bone benefits to short-chain fatty acids, small molecules made by gut bacteria.

Experiments in miceMetformin