FBXO7

1. FBXO7 inhibits JAK–STAT signalling in human cells.

   “This ubiquitination suppresses IL-6-mediated activation of the JAK1/STAT3 signaling pathway”

   Cellsspecifically at lysine 114

   FBXO7 protects against osteoarthritis by promoting IL-6 ubiquitination and inhibiting JAK1/STAT3 signaling

   International immunopharmacology·8 May 2026

More on JAK–STAT signalling

1. FBXO7 decreases cellular senescence in human cells.

   “FBXO7 overexpression significantly reduced chondrocyte apoptosis and senescence while enhancing proliferation”

   CellsFBXO7 overexpression in chondrocytes

   FBXO7 protects against osteoarthritis by promoting IL-6 ubiquitination and inhibiting JAK1/STAT3 signaling

   International immunopharmacology·8 May 2026

More on Cellular senescence

1. FBXO7 decreases cartilage degradation in mice.

   “Fbxo7 conditional knockout mice exhibited accelerated cartilage degradation, enhanced synovial inflammation, and increased cellular senescence.”

   Animalsdestabilization of the medial meniscus (DMM)cartilage

   FBXO7 protects against osteoarthritis by promoting IL-6 ubiquitination and inhibiting JAK1/STAT3 signaling

   International immunopharmacology·8 May 2026