PSMF1

1. PSMF1 decreases phosphorylated tau in mice.

   “Fbxo7 inactivation in mouse neurons causes hyperphosphorylation of tau, and this was suppressed by transgenic expression of PI31”

   Animalsin Fbxo7-inactivated mouse neurons

   PI31 expression is neuroprotective in a mouse model of early-onset parkinsonism

   Proceedings of the National Academy of Sciences of the United States of America·16 Sep 2025

More on Phosphorylated tau

1. PSMF1 improves neuronal function in mice.

   “significantly improves neuronal function, health, and lifespan”

   Animalsin Fbxo7 mutant fly and mouse strains

   PI31 expression is neuroprotective in a mouse model of early-onset parkinsonism

   Proceedings of the National Academy of Sciences of the United States of America·16 Sep 2025

1. PSMF1 extends lifespan in mice.

   “significantly improves neuronal function, health, and lifespan”

   Animalsin Fbxo7 mutant strains

   PI31 expression is neuroprotective in a mouse model of early-onset parkinsonism

   Proceedings of the National Academy of Sciences of the United States of America·16 Sep 2025

1. PSMF1 prevents neuronal degeneration in mice.

   “restoring PI31 levels in Fbxo7 mutant fly and mouse strains prevents neuronal degeneration”

   Animalsin Fbxo7 mutant strains

   PI31 expression is neuroprotective in a mouse model of early-onset parkinsonism

   Proceedings of the National Academy of Sciences of the United States of America·16 Sep 2025