ENDOG
None of its findings points the other way.
- 3 independent labs in 3 countries
- Funders: Bundesministerium für Forschung, Technologie und Raumfahrt and 2 more
- Animals2
- Cells3
Effects
9Apoptosis
upin human cells2
2 studies
Apoptosis
upin human cells2
ENDOG activates apoptosis in human cells.
“activation of the BCL2/BAX-associated apoptotic pathway finally leading to cell death.”
Cellslong-term in vitro cultivationCD4+ T cells
European journal of cell biology
ENDOG activates apoptosis in human cells.
“activation of apoptosis, and finally cell death.”
CellsEndoG overexpression
Biochemistry. Biokhimiia
Cellular senescence
upin human cells2
2 studies
Cellular senescence
upin human cells2
ENDOG induces cellular senescence in human cells.
“conversion of cells into a replicative senescence state”
Cellslong-term in vitro cultivationCD4+ T cells
European journal of cell biology
ENDOG induces cellular senescence in human cells.
“converted cells into the replicative senescence state”
CellsEndoG overexpression
Biochemistry. Biokhimiia
Oxidative stress and ROS signaling
is required forin cells1downin cells1
1 study
Oxidative stress and ROS signaling
is required forin cells1downin cells1
ENDOG is required for oxidative stress and ROS signaling in cells.
“down-regulation of Endog blunted the protective role of metformin in defending against FAs-induced oxidative stress.”
Cellsin defending against FAs-induced oxidative stress
Clinical science (London, England : 1979)
ENDOG protects against oxidative stress and ROS signaling in cells.
“ENDOG protects hepatocytes from lipid-induced oxidative stress”
Cellslipid-induced
Clinical science (London, England : 1979)
Telomere length
downin human cells1
1 study
Telomere length
downin human cells1
ENDOG decreases telomere length in human cells.
“Long-term in vitro cultivation of EndoG-overexpressing CD4+ T cells led to dramatically shortened telomeres”
Cellslong-term in vitro cultivationCD4+ T cells
European journal of cell biology
TERT
downin human cells1
1 study
TERT
downin human cells1
ENDOG decreases TERT in human cells.
“Overexpression of EndoG in CD4+ T cells down-regulated the expression of the active full-length hTERT variant”
CellsEndoG overexpressionCD4+ T cells
European journal of cell biology
DNA damage response
is required forin human cells1
1 study
DNA damage response
is required forin human cells1
ENDOG is required for DNA damage response in human cells.
“We demonstrate that upon γ-irradiation in HDFs EndoG translocates into the nucleus playing an essential role in the non-lethal cleavage of damaged DNA.”
Cellsin senescent HDFs after ionizing radiation
Senoptosis: non-lethal DNA cleavage as a route to deep senescence
Oncotarget
Mortality
upin mice1
1 study
Mortality
upin mice1
ENDOG increases mortality in mice.
“can form tumors and cause death in experimental mice.”
Animalsxenograft of transformed human CD4+ T cells
Biochemistry. Biokhimiia
Precursor T-cell lymphoblastic leukemia/lymphoma
upin human cells1
1 study
Precursor T-cell lymphoblastic leukemia/lymphoma
upin human cells1
ENDOG induces precursor T-cell lymphoblastic leukemia/lymphoma in human cells.
“Some cells survive and undergo a malignant transformation.”
CellsEndoG-overexpressing CD4+ T cells surviving senescence/death
Biochemistry. Biokhimiia
telomerase-maintenance
downin human cells1
1 study
telomerase-maintenance
downin human cells1
ENDOG decreases telomerase-maintenance in human cells.
“Reduction of full-length hTERT levels caused downregulation of the telomerase activity”
CellsEndoG overexpression
Biochemistry. Biokhimiia