EML4-ALK
2 papers2 findings
- 1 lab in 1 country
- Funders: Moffitt Cancer Center and 1 more
- Animals1
Effects
2Lung cancer
upin naked mole-rats1+30% tumor penetrance
1 study
Lung cancer
upin naked mole-rats1+30% tumor penetrance
EML4-ALK induces lung cancer in naked mole-rats (30% tumor penetrance).
“naked mole rats require three simultaneous oncogenic events: Eml4-Alk, Tp53 loss, and Rb1 loss, achieving only 30% tumor penetrance.”
Reviewthree simultaneous oncogenic events (Eml4-Alk, Tp53 loss, and Rb1 loss)
Testing Nature's Defenses: Inducing Cancer in the Naked Mole Rat
Cancer discovery12 Jan 2026
Lung tumor initiation
no changein naked mole-rats1
1 study
Lung tumor initiation
no changein naked mole-rats1
EML4-ALK has no effect on lung tumor initiation in naked mole-rats.
“the inversion alone was insufficient to drive tumorigenesis in the NMR lung”
Animalsalonelung
Cancer discovery8 Sep 2025
Latest
1 in 12 monthsCancer Discovery
Testing Nature's Defenses: Inducing Cancer in the Naked Mole Rat
CommentaryMechanisms
Cancer Discovery
An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat
Experiments in naked mole-ratsLung