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PRB

Gene

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Moffitt Cancer Center and 1 more
  • Animals1

Effects

1

Lung tumor initiation

is required forin naked mole-rats1

1 study

  1. PRB is required for lung tumor initiation in naked mole-rats.

    “tumor development required additional losses of the tumor suppressors p53 and pRb”

    Animalswith Eml4-Alk fusionlung

    An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat

    Cancer discovery8 Sep 2025

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