Egr

1. Egr is required for extracellular matrix remodelling in E. fraudatrix.

   “Knockdown of egr during regeneration leads to abnormalities in gut development, including thickening of the intestinal tube, improper lumen formation, excessive loosening of the extracellular matrix”

   Model organismsduring visceral organ regeneration, shown by knockdowngut

   Egr gene in visceral organ regeneration in the holothurian eupentacta fraudatrix

   Tissue & cell·28 Aug 2026

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1. Egr activates JNK signalling in flies.

   “Egr preferentially activates JNK signaling in a paracrine fashion in differentiated enterocytes (ECs) via its receptor, Grindelwald (Grnd).”

   Model organismsparacrine signaling via Grindelwaldenterocyte

   Inter-cell type interactions that control JNK signaling in the Drosophila intestine

   Nature communications·28 Jun 2024

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