Reproduction

2 papers3 findings

MeSH D012098

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: National Science Foundation and others

Animals2

Outcomes

Relative telomere length

downin R. ferrumequinum1

1 study

Reproduction decreases relative telomere length in R. ferrumequinum.
“females breeding from 2 y of age had significantly shorter relative TL (rTL) compared to females delaying reproduction until later ages.”
Animalsfemales
Short- and long-term costs of reproduction revealed by telomere dynamics in wild greater horseshoe bats
Proceedings of the National Academy of Sciences of the United States of America1 Dec 2025