There are 6 papers on dome in aging research: none in people yet, 6 in animals.
At a glance
The findings reach worms or flies, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: Biotechnology and Biological Sciences Research Council and 7 more
- Model organisms6
Effects
2PI3K–AKT signaling
downin flies1
1 study
PI3K–AKT signaling
downin flies1
dome inhibits PI3K–AKT signaling in flies (AKT hyperactivation upon loss of the dome receptor in muscle).
“These pathologies result from hyperactivation of AKT and consequent deregulation of metabolism.”
Model organismsAKT hyperactivation upon loss of the dome receptor in musclemuscle
Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila
eLife
Lifespan
upin flies1
1 study
Lifespan
upin flies1
dome extends lifespan in flies (shown by loss of the dome receptor in adult muscle).
“Loss of the dome receptor on adult muscles significantly reduces lifespan and causes local and systemic metabolic pathology.”
Model organismsshown by loss of the dome receptor in adult musclemuscle
Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila
eLife