There is 1 paper on Domeless in aging research: none in people yet, 1 in animals.
At a glance
The findings reach worms or flies, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: Agence Nationale de la Recherche and 2 more
- Model organisms1
Effects
3Triglyceride accumulation
upin flies1
1 study
Triglyceride accumulation
upin flies1
Domeless increases triglyceride accumulation in flies (shown by knockdown in fat body on high sugar diet).
“Additionally, the loss of Domeless reduced the accumulation of triglycerides in the fat body cells of larvae fed HSD and also significantly increased the lifespan of adult flies.”
Model organismsshown by knockdown in fat body on high sugar dietfat body
Scientific reports
Nlaz
upin flies1
1 study
Nlaz
upin flies1
Domeless increases Nlaz in flies (shown by knockdown in fat body on high sugar diet).
“Domeless receptor loss in fat body cells reverses both hyperglycemia and the increase in the expression of the insulin resistance marker Nlaz”
Model organismsshown by knockdown in fat body on high sugar dietfat body
Scientific reports
Hyperglycemia
upin flies1
1 study
Hyperglycemia
upin flies1
Domeless increases hyperglycemia in flies (shown by knockdown in fat body on high sugar diet).
“Domeless receptor loss in fat body cells reverses both hyperglycemia and the increase in the expression of the insulin resistance marker Nlaz”
Model organismsshown by knockdown in fat body on high sugar dietfat body
Scientific reports