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DNAJC5

Gene

1 paper1 finding

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Biotechnology and Biological Sciences Research Council and 4 more
  • Cells1

Effects

1

misfolded protein secretion

is required forin human cells1

1 study

  1. DNAJC5 is required for misfolded protein secretion in human cells.

    “through a process that requires the vesicle-associated HSP70 co-chaperone DNAJC5”

    CellsRequired for endo-lysosomal secretion by senescent cells during acute or chronic stress

    Declining intracellular proteostasis capacity drives misfolded protein secretion in senescent human cells

    bioRxiv (Cold Spring Harbor Laboratory)8 Sep 2025Preprint

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