Intracellular HSP levels

Intracellular HSP levels decrease misfolded protein secretion in human cells.

“Misfolded protein secretion could be rescued by increasing intracellular HSP levels in ‘shallow’ but not ‘deep’ senescence”

CellsIncreasing intracellular HSP levels in shallow, but not deep, senescence

Declining intracellular proteostasis capacity drives misfolded protein secretion in senescent human cells

bioRxiv (Cold Spring Harbor Laboratory)·8 Sep 2025Preprint