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CSF2RB

Gene

1 paper studies it2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Alzheimer's Association and 5 more
  • Animals1

Effects

2

Cellular senescence

downin human cells1

1 study

  1. CSF2RB decreases cellular senescence in human cells.

    “ameliorating senescent and dystrophic phenotypes in human microglia”

    Cellsin human microglia treated with pathological taumicroglia

    A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimer's Disease

    bioRxiv : the preprint server for biologyMar 14, 2024Preprint

More on Cellular senescence

Type I interferon signaling

downin human cells1

1 study

  1. CSF2RB inhibits type I interferon signaling in human cells.

    “in response to pathological tau, the CSF2RB A455D mutation suppresses microglial type-1 interferon signaling”

    Cellsin response to pathological taumicroglia

    A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimer's Disease

    bioRxiv : the preprint server for biologyMar 14, 2024Preprint

More on Type I interferon signaling

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