CATALASE

Gene

4 papers study it4 findings

Taxon

  • 2 independent labs in 2 countries
  • Funders: Cancer Prevention and Research Institute of Texas and others
  • Animals3
  • Cells1

Effects

4

Vasodilation

downin mice1

1 study
  1. CATALASE inhibits vasodilation in mice.

    “Acetylcholine-induced vasodilation in 8-week-old E3L.CETP, especially female mice, was blocked by catalase and attributed to H2O2.”

    Animalsin E3L.CETP miceacetylcholine-inducedvesselfemales

    Effects of life-long hyperlipidaemia on age-dependent development of endothelial dysfunction in humanised dyslipidaemic mice

    GeroScience

Influenza-specific T cells

upin mice1

1 study
  1. CATALASE increases influenza-specific T cells in mice.

    “it mitigates declining production of influenza-specific T cells and their frequency in lung after infection”

    Animalsafter influenza infection

    Redox regulation of age-associated defects in generation and maintenance of T cell self-tolerance and immunity to foreign antigens

    Cell reports

More on Influenza-specific T cells

Thymic atrophy

downin mice1

1 study
  1. CATALASE decreases thymic atrophy in mice.

    “Increased catalase activity delays thymic atrophy”

    Animalsaging

    Redox regulation of age-associated defects in generation and maintenance of T cell self-tolerance and immunity to foreign antigens

    Cell reports

Lifespan

upin mice1

1 study
  1. CATALASE extends lifespan in mice.

    “Transgenic expression of catalase in mitochondria using a transgenic strategy extends life span”

    Reviewtransgenic overexpression

    Mitochondria-targeted antiaging gene therapy with adeno-associated viral vectors

    Methods in molecular biology (Clifton, N.J.)

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