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BRAP

Gene

2 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Uniformed Services University of the Health Sciences and 4 more
  • Animals2

Effects

4

Cerebrovascular defects

downin animals1

1 study

  1. BRAP protects against cerebrovascular defects.

    “abrogating the BRCA1-associated protein Brap in cerebral cortical neurons, as opposed to vascular endothelium cells, causes cerebrovascular defects.”

    Animalsshown by Brap abrogationcerebral cortical neuron

    Senescence of cortical neurons following persistent DNA double-strand breaks induces cerebrovascular lesions

    bioRxiv (Cold Spring Harbor Laboratory)Jan 27, 2023Preprint

Neurodegeneration

downin mice1

1 study

  1. BRAP decreases neurodegeneration in mice.

    “Brap deletion in the mouse brain causes neuroinflammation, impaired proteostasis, accelerated neurodegeneration, and substantially shortened the lifespan.”

    Animalsshown by Brap deletionbrain

    Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration

    iScienceJun 3, 2022

Proteostasis

upin mice1

1 study

  1. BRAP improves proteostasis in mice.

    “Brap deletion in the mouse brain causes neuroinflammation, impaired proteostasis, accelerated neurodegeneration, and substantially shortened the lifespan.”

    Animalsshown by Brap deletionbrain

    Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration

    iScienceJun 3, 2022

More on Proteostasis

Histone H2A ubiquitination

downin mice1

1 study

  1. BRAP decreases histone H2A ubiquitination in mice.

    “abrogating Brap, a BRCA1-associated protein essential for neurogenesis, results in persistent DNA double-strand breaks and elevation of histone H2A mono- and poly-ubiquitination (H2Aub).”

    Animalsshown by Brap loss of function

    Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration

    iScienceJun 3, 2022

More on Histone H2A ubiquitination

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